Antipsychotics for Treating Delirium in Hospitalized Adults: A Systematic Review

Abstract

Background
Delirium is common in hospitalized patients and is associated with worse outcomes. Antipsychotics are commonly used; however, the associated benefits and harms are unclear.

Purpose
To conduct a systematic review evaluating the benefits and harms of antipsychotics to treat delirium in adults.

Data Sources
PubMed, Embase, CENTRAL, CINAHL, and PsycINFO from inception to July 2019 without language restrictions.

Study Selection
Randomized controlled trials (RCTs) of antipsychotic versus placebo or another antipsychotic, and prospective observational studies reporting harms.

Data Extraction
One reviewer extracted data and assessed strength of evidence (SOE) for critical outcomes, with confirmation by another reviewer. Risk of bias was assessed independently by 2 reviewers.

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